In the late 1930s, the Toronto post office applied a three-digit numeral handstamp on some air mail letters addressed to foreign destinations. I have seen three different handstamps, "741" , "821", and "821 A" on covers mailed from 1937 to 1939 . Unfortunately I have been unable to find the reason why the numbers were used.
741
The only 741 handstamp I have seen has serifed numerals.
April 1, 1938 (Station "K")
Air mail to Curacao, Dutch West Indies
May 26, 1939
Air mail to Tucson, Arizona
October 1, 1939
Air mail to Tacoma, Washington
821
The 821 handstamp exists serifed and sans-serif
Serif
August 11, 1937 (Toronto Station "A")
Air mail to Des Moines, Iowa
November 8, 1937
Air mail to New York then South Africa
December 15, 1937 (Toronto Station "A")
Air mail to Honolulu, Hawaii
Sans-serif
December 11, 1939
Air mail to Colorado Springs, Colorado
821 A
The only 821 A I have seen is a sans-serif handstamp.
October 31, 1939
Air Mail from London, Ontario (Toronto transit) to London, England
September 8, 1939
Toronto to Bombay, India
821 A struck out with pencil